Biology:4F2 cell-surface antigen heavy chain
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Short description: Protein found in humans
 Generic protein structure example |
4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene.[1][2]
SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98).[3][4]
Function
SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.[5] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.[5]
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
- 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene)[6]
- CD98 light subunit protein encoded by the SLC7A5 gene[7]
Interactions
SLC3A2 has been shown to interact with SLC7A7.[8]
Additionally, SLC3A2 is a constituent member of the system xc- cystine/glutamate antiporter, complexing with SLC7A11.
See also
- Heterodimeric amino acid transporter
References
- ↑ "Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus". J Biol Chem 262 (20): 9574–80. Aug 1987. doi:10.1016/S0021-9258(18)47972-0. PMID 3036867.
- ↑ 2.0 2.1 "Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6520.
- ↑ "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. 2005. doi:10.1038/labinvest.3700289. PMID 15880135.
- ↑ "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics 5 (14): 3637–45. 2005. doi:10.1002/pmic.200401224. PMID 16097038.
- ↑ 5.0 5.1 "Selective expression of the large neutral amino acid transporter at the blood–brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. 1999. doi:10.1073/pnas.96.21.12079. PMID 10518579. Bibcode: 1999PNAS...9612079B.
- ↑ "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch 447 (5): 490–494. 2004. doi:10.1007/s00424-003-1062-7. PMID 14770309.
- ↑ "CATs and HATs: the SLC7 family of amino acid transporters". Pflügers Arch 447 (5): 532–542. 2004. doi:10.1007/s00424-003-1086-z. PMID 14770310. http://doc.rero.ch/record/317805/files/424_2003_Article_1086.pdf.
- ↑ "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". EMBO J. 18 (1): 49–57. Jan 1999. doi:10.1093/emboj/18.1.49. PMID 9878049.
Further reading
- "A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus". Genomics 14 (1): 26–31. 1992. doi:10.1016/S0888-7543(05)80278-2. PMID 1358795.
- "Inhibition of Na+/Ca2+ exchanger activity in cardiac and skeletal muscle sarcolemmal vesicles by monoclonal antibody 44D7". J. Biol. Chem. 261 (1): 92–5. 1986. doi:10.1016/S0021-9258(17)42436-7. PMID 2416754.
- "Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation". Mol. Cell. Biol. 8 (9): 3809–19. 1989. doi:10.1128/mcb.8.9.3809. PMID 3265470.
- "Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms". Mol. Cell. Biol. 8 (9): 3820–6. 1989. doi:10.1128/mcb.8.9.3820. PMID 3265471.
- "Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth". Proc. Natl. Acad. Sci. U.S.A. 84 (18): 6526–30. 1987. doi:10.1073/pnas.84.18.6526. PMID 3476959. Bibcode: 1987PNAS...84.6526Q.
- "Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9204–8. 1988. doi:10.1073/pnas.84.24.9204. PMID 3480538.
- "Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion". J. Clin. Endocrinol. Metab. 64 (1): 43–50. 1987. doi:10.1210/jcem-64-1-43. PMID 3782435.
- "Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines". J. Immunol. 129 (2): 623–8. 1982. doi:10.4049/jimmunol.129.2.623. PMID 6177771.
- "Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen". Somatic Cell Genet 8 (6): 825–34. 1983. doi:10.1007/BF01543022. PMID 6187076.
- "Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11". Somatic Cell Genet 9 (3): 333–44. 1983. doi:10.1007/BF01539142. PMID 6190235.
- "Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes". J. Immunol. 126 (4): 1409–14. 1981. doi:10.4049/jimmunol.126.4.1409. PMID 7204970.
- "Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules". J. Immunol. 155 (7): 3585–92. 1995. doi:10.4049/jimmunol.155.7.3585. PMID 7561057.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Regulation of human immunodeficiency virus gp160-mediated cell fusion by antibodies against fusion regulatory protein 1". J. Gen. Virol. 77 (11): 2747–56. 1996. doi:10.1099/0022-1317-77-11-2747. PMID 8922468.
- "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics 37 (3): 354–65. 1997. doi:10.1006/geno.1996.0570. PMID 8938448.
- "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160". Med. Microbiol. Immunol. 186 (2–3): 115–23. 1998. doi:10.1007/s004300050053. PMID 9403839.
External links
- Large+Neutral+Amino+Acid-Transporter+1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Amino+Acid+Transport+System+L at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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