Biology:CD98
From HandWiki
Short description: Family of protein complexes
| solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport) | |
|---|---|
| Identifiers | |
| Symbol | SLC3A2 |
| Alt. symbols | MDU1, 4T2HC, 4F2, NACAE, CD98 |
| NCBI gene | 6520 |
| HGNC | 11026 |
| OMIM | 158070 |
| RefSeq | NM_001013251 |
| UniProt | P08195 |
| Other data | |
| Locus | Chr. 11 q12-q22 |
| solute carrier family 7 member 5 (cationic amino acid transporter, y+ system) | |
|---|---|
| Identifiers | |
| Symbol | SLC7A5 |
| Alt. symbols | LAT1, E16, D16S469E, MPE16, CD98 |
| NCBI gene | 8140 |
| HGNC | 11063 |
| OMIM | 600182 |
| RefSeq | NM_003486 |
| UniProt | Q01650 |
| Other data | |
| Locus | Chr. 16 q24.3 |
CD98 is a glycoprotein[1][2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.[3]
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
- 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene [4]
- CD98 light subunit protein encoded by the SLC7A5 gene[5]
See also
References
- ↑ "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. 2005. doi:10.1038/labinvest.3700289. PMID 15880135.
- ↑ "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics 5 (14): 3637–45. 2005. doi:10.1002/pmic.200401224. PMID 16097038.
- ↑ 3.0 3.1 "Selective expression of the large neutral amino acid transporter at the blood–brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. 1999. doi:10.1073/pnas.96.21.12079. PMID 10518579. Bibcode: 1999PNAS...9612079B.
- ↑ "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch 447 (5): 490–494. 2004. doi:10.1007/s00424-003-1062-7. PMID 14770309.
- ↑ "CATs and HATs: the SLC7 family of amino acid transporters". Pflügers Arch 447 (5): 532–542. 2004. doi:10.1007/s00424-003-1086-z. PMID 14770310. http://doc.rero.ch/record/317805/files/424_2003_Article_1086.pdf.
External links
- CD98+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
- Large+Neutral+Amino+Acid-Transporter+1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Amino+Acid+Transport+System+L at the US National Library of Medicine Medical Subject Headings (MeSH)
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