Biology:ACV synthetase
From HandWiki
Short description: Class of enzymes
| N-(5-Amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.3.2.26 | ||||||||
| CAS number | 57219-73-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
ACV synthetase (ACVS, L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synthetase, N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase, EC 6.3.2.26) is an enzyme that catalyzes the chemical reaction
- 3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 3 AMP + 3 PPi + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
The five substrates of this enzyme are ATP, L-2-aminohexanedioate, L-cysteine, L-valine, and H2O, whereas its three products are AMP, diphosphate, and N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine.
ACVS is an example of a nonribosomal peptide synthetase (NRPS). It participates in penicillin and cephalosporin biosyntheses.
References
- "The Mechanism of ACV Synthetase". Chem. Rev. 97 (7): 2631–2650. 1997. doi:10.1021/cr960018l. PMID 11851475.
- "Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum". Biochem. J. 327 (Pt 1): 185–91. 1997. doi:10.1042/bj3270185. PMID 9355751.
 |  |
