Biology:ATP12A
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene.[1][2][3][4]
Function
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.[2]
References
- ↑ "ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene & protein" (in en). https://www.uniprot.org/uniprot/P54707.
- ↑ 2.0 2.1 "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=479.
- ↑ "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics 32 (3): 317–27. March 1996. doi:10.1006/geno.1996.0125. PMID 8838794.
- ↑ "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics 2 (2): 128–38. February 1988. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
External links
- Human ATP12A genome location and ATP12A gene details page in the UCSC Genome Browser.
Further reading
- "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.". FEBS Lett. 278 (1): 91–4. 1991. doi:10.1016/0014-5793(91)80091-G. PMID 1847115.
- "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.". Genomics 2 (2): 128–38. 1988. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
- "Multiple genes encode the human Na+,K+-ATPase catalytic subunit.". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. 1987. doi:10.1073/pnas.84.12.4039. PMID 3035563.
- "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.". FEBS Lett. 217 (2): 275–8. 1987. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
- "Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family.". FEBS Lett. 349 (1): 144–50. 1994. doi:10.1016/0014-5793(94)00655-5. PMID 8045293.
- "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase.". Genomics 32 (3): 317–27. 1997. doi:10.1006/geno.1996.0125. PMID 8838794.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit.". FEBS Lett. 440 (3): 320–4. 1999. doi:10.1016/S0014-5793(98)01483-5. PMID 9872395.
- "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization.". Am. J. Physiol., Cell Physiol. 282 (4): C907–16. 2002. doi:10.1152/ajpcell.00258.2001. PMID 11880279.
- "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1.". Am. J. Physiol. Renal Physiol. 283 (2): F335–43. 2002. doi:10.1152/ajprenal.00226.2001. PMID 12110518.
- "Expression of ATP1AL1, a non-gastric proton pump, in human colorectum.". Jpn. J. Physiol. 52 (3): 317–21. 2003. doi:10.2170/jjphysiol.52.317. PMID 12230809.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function.". Kidney Int. 65 (4): 1301–10. 2004. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
- "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast.". Placenta 25 (6): 505–11. 2004. doi:10.1016/j.placenta.2003.11.008. PMID 15135233.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
 |
