Biology:Apolipoprotein C-II
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
| Apo-CII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 nmr structure of human apolipoprotein c-ii in the presence of sds | |||||||||
| Identifiers | |||||||||
| Symbol | Apo-CII | ||||||||
| Pfam | PF05355 | ||||||||
| InterPro | IPR008019 | ||||||||
| SCOP2 | 1by6 / SCOPe / SUPFAM | ||||||||
| |||||||||
Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene.
The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries,[1] which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons[2]
Interactive pathway map
See also
- Apolipoprotein C
References
- ↑ "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. 2006. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153.
- ↑ "Entrez Gene: APOC2 apolipoprotein C-II". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=344.
- "Primary structure of very low density apolipoprotein C-II of human plasma.". Proc. Natl. Acad. Sci. U.S.A. 74 (5): 1942–5. 1977. doi:10.1073/pnas.74.5.1942. PMID 194244. Bibcode: 1977PNAS...74.1942J.
- "Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII.". Eur. J. Biochem. 205 (1): 223–31. 1992. doi:10.1111/j.1432-1033.1992.tb16772.x. PMID 1555583.
- "An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia.". Dis. Markers 9 (2): 73–80. 1992. PMID 1782747.
- "Identification of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency (Apo CII-Bari).". Biochem. Biophys. Res. Commun. 168 (3): 1118–27. 1990. doi:10.1016/0006-291X(90)91145-I. PMID 1971748.
- "Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing.". Eur. J. Biochem. 192 (2): 515–21. 1990. doi:10.1111/j.1432-1033.1990.tb19255.x. PMID 2209608.
- "The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes.". J. Biol. Chem. 260 (28): 15211–21. 1986. doi:10.1016/S0021-9258(18)95724-8. PMID 2415514.
- "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency.". J. Clin. Invest. 84 (4): 1215–9. 1989. doi:10.1172/JCI114287. PMID 2477392.
- "Isolation of cDNA and genomic clones for apolipoprotein C-II". Meth. Enzymol.. Methods in Enzymology 128: 788–800. 1986. doi:10.1016/0076-6879(86)28106-9. ISBN 9780121820282. PMID 3014272. https://archive.org/details/plasmalipoprotei0000unse/page/788.
- "The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization". FEBS Lett. 213 (1): 221–6. 1987. doi:10.1016/0014-5793(87)81495-3. PMID 3030808.
- "A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II". J. Biol. Chem. 263 (34): 17913–6. 1989. doi:10.1016/S0021-9258(19)81302-9. PMID 3192518.
- "Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency". J. Clin. Invest. 82 (5): 1489–94. 1988. doi:10.1172/JCI113756. PMID 3263393.
- "Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 84 (1): 270–3. 1987. doi:10.1073/pnas.84.1.270. PMID 3467353. Bibcode: 1987PNAS...84..270C.
- "Human plasma apolipoprotein C-II: total solid-phase synthesis and chemical and biological characterization". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4796–800. 1987. doi:10.1073/pnas.84.14.4796. PMID 3474626. Bibcode: 1987PNAS...84.4796F.
- "Human preproapolipoprotein C-II. Analysis of major plasma isoforms". J. Biol. Chem. 261 (21): 9591–4. 1986. doi:10.1016/S0021-9258(18)67554-4. PMID 3525527.
- "The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron". J. Biol. Chem. 262 (10): 4787–93. 1987. doi:10.1016/S0021-9258(18)61264-5. PMID 3558370.
- "Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease". J. Clin. Invest. 80 (6): 1597–606. 1988. doi:10.1172/JCI113246. PMID 3680515.
- "Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients". J. Clin. Invest. 77 (2): 520–7. 1986. doi:10.1172/JCI112332. PMID 3944267.
- "A variant primary structure of apolipoprotein C-II in individuals of African descent". J. Clin. Invest. 77 (2): 595–601. 1986. doi:10.1172/JCI112342. PMID 3944271.
- "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Res. 12 (9): 3917–32. 1984. doi:10.1093/nar/12.9.3917. PMID 6328445.
- "Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII". Proc. Natl. Acad. Sci. U.S.A. 81 (10): 2945–9. 1984. doi:10.1073/pnas.81.10.2945. PMID 6328478. Bibcode: 1984PNAS...81.2945J.
External links
- Human APOC2 genome location and APOC2 gene details page in the UCSC Genome Browser.
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