Biology:Archaeosine synthase
From HandWiki
Short description: Enzyme
| Archaeosine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.97 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Archaeosine synthase (EC 2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase.[1][2] This enzyme catalyses the following chemical reaction
- L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O [math]\displaystyle{ \rightleftharpoons }[/math] L-glutamate + archaeine15 in tRNA
In Euryarchaeota the reaction is catalysed by ArcS.
References
- ↑ "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". The Journal of Biological Chemistry 285 (17): 12706–13. April 2010. doi:10.1074/jbc.M110.102236. PMID 20129918.
- ↑ "Diversity of archaeosine synthesis in crenarchaeota". ACS Chemical Biology 7 (2): 300–5. February 2012. doi:10.1021/cb200361w. PMID 22032275.
External links
- Archaeosine+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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