Biology:Auxilin
 Generic protein structure example |
Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[1][2][3]
Function
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[3]
Structure
The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.[4] The phosphatase domain belongs to the auxilin subfamily of lipid phosphatases and is predicted to be catalytically inactive.[5][6]
References
- ↑ "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research 4 (5): 345–9. October 1997. doi:10.1093/dnares/4.5.345. PMID 9455484.
- ↑ "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones 5 (2): 98–112. April 2000. PMID 11147971.
- ↑ 3.0 3.1 "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9829.
- ↑ "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science 24 (5): 874–82. May 2015. doi:10.1002/pro.2664. PMID 25694109.
- ↑ "Phosphatase Subfamily Auxilin - PhosphataseWiki" (in en). http://phosphatome.net/wiki/index.php/Phosphatase_Subfamily_Auxilin.
- ↑ "Genomics and evolution of protein phosphatases" (in en). Science Signaling 10 (474): eaag1796. April 2017. doi:10.1126/scisignal.aag1796. PMID 28400531.
External links
- Human DNAJC6 genome location and DNAJC6 gene details page in the UCSC Genome Browser.
Further reading
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. September 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry 278 (28): 25357–68. July 2003. doi:10.1074/jbc.M303738200. PMID 12732633.
- "Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex". The Journal of Biological Chemistry 276 (39): 36131–8. September 2001. doi:10.1074/jbc.M106511200. PMID 11470803.
- "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research 4 (5): 307–13. October 1997. doi:10.1093/dnares/4.5.307. PMID 9455477.
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