Biology:Bile salt sulfotransferase

Generic protein structure example

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.

See also

• Steroid sulfotransferase
• Steroidogenic enzyme

Further reading

• "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3–14. 1997. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. 
• "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113: 341–8. 2000. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750. 
• "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1–2): 27–40. 2001. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246. 
• "Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver.". Biochem. Biophys. Res. Commun. 187 (1): 448–54. 1992. doi:10.1016/S0006-291X(05)81514-1. PMID 1520333. 
• "Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenal.". Mol. Pharmacol. 41 (4): 645–51. 1992. PMID 1569919. 
• "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA.". Mol. Pharmacol. 41 (5): 865–72. 1992. PMID 1588921. 
• "Human liver steroid sulphotransferase sulphates bile acids.". Biochem. J. 272 (3): 597–604. 1991. doi:10.1042/bj2720597. PMID 2268288. 
• "Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme.". Mol. Cell. Endocrinol. 112 (1): 53–60. 1995. doi:10.1016/0303-7207(95)03585-U. PMID 7589785. 
• "Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene.". DNA Cell Biol. 14 (6): 511–8. 1995. doi:10.1089/dna.1995.14.511. PMID 7598806. 
• "Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.". Biochem. J. 289 (1): 233–40. 1993. doi:10.1042/bj2890233. PMID 7678732. 
• "Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization.". DNA Cell Biol. 14 (4): 331–41. 1995. doi:10.1089/dna.1995.14.331. PMID 7710689. 
• "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3.". Cytogenet. Cell Genet. 70 (1–2): 45–7. 1995. doi:10.1159/000133988. PMID 7736787. https://zenodo.org/record/1235412. 
• "Steroid sulfation by expressed human cytosolic sulfotransferases.". J. Steroid Biochem. Mol. Biol. 48 (4): 369–75. 1994. doi:10.1016/0960-0760(94)90077-9. PMID 8142314. 
• "Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes.". Endocrinology 134 (2): 982–9. 1994. doi:10.1210/en.134.2.982. PMID 8299591. 
• "Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region.". Genomics 29 (3): 781–3. 1996. doi:10.1006/geno.1995.9935. PMID 8575776. 
• "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy.". Mol. Hum. Reprod. 5 (11): 995–1002. 1999. doi:10.1093/molehr/5.11.995. PMID 10541560. 
• "Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa.". J. Steroid Biochem. Mol. Biol. 72 (3–4): 149–54. 2000. doi:10.1016/S0960-0760(00)00020-0. PMID 10775806. 
• "Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase.". FEBS Lett. 475 (1): 61–4. 2000. doi:10.1016/S0014-5793(00)01479-4. PMID 10854859. 

External links

• alcohol+sulfotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human SULT2A1 genome location and SULT2A1 gene details page in the UCSC Genome Browser.