Biology:Carboxynorspermidine synthase
From HandWiki
| Carboxynorspermidine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.1.43 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carboxynorspermidine synthase (EC 1.5.1.43, carboxynorspermidine dehydrogenase, carboxyspermidine dehydrogenase, CASDH, CANSDH) is an enzyme with systematic name carboxynorspermidine:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reactions
- (1) carboxynorspermidine + H2O + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
- (2) carboxyspermidine + H2O + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] L-aspartate 4-semialdehyde + putrescine + NADPH + H+
The reaction takes place in the opposite direction.
References
- ↑ "Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus". Journal of General Microbiology 137 (7): 1737–42. July 1991. doi:10.1099/00221287-137-7-1737. PMID 1955861.
- ↑ "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae". The Journal of Biological Chemistry 284 (15): 9899–907. April 2009. doi:10.1074/jbc.M900110200. PMID 19196710.
- ↑ "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota". The Journal of Biological Chemistry 286 (50): 43301–12. December 2011. doi:10.1074/jbc.M111.307835. PMID 22025614.
External links
- Carboxynorspermidine+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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