Biology:Cytokinin dehydrogenase
| Cytokinin dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.99.12 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Cytokinin dehydrogenase (EC 1.5.99.12) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The three substrates of this enzyme are a cytokinin such as N6-isopentenyladenine, an electron acceptor, and water. Its products are adenine, 3-methyl-2-butenal (or other aldehyde in case of different substrates), and the corresponding reduced acceptor.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N6-dimethylallyladenine:acceptor oxidoreductase. Other names in common use include N6-dimethylallyladenine:(acceptor) oxidoreductase, 6-N-dimethylallyladenine:acceptor oxidoreductase, and cytokinin oxidase/dehydrogenase abbreviated as CKX.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1W1O, 1W1Q, 1W1R, 1W1S, 2EXR, and 2Q4W. As of 2026[update], there have been 18 structures recorded.[4]
References
- ↑ Enzyme 1.5.99.12 at KEGG Pathway Database.
- ↑ "Cytokinin oxidase or dehydrogenase? Mechanism of cytokinin degradation in cereals". European Journal of Biochemistry 268 (2): 450–461. January 2001. doi:10.1046/j.1432-1033.2001.01910.x. PMID 11168382.
- ↑ "Cytokinin oxidase regulates rice grain production". Science 309 (5735): 741–745. July 2005. doi:10.1126/science.1113373. PMID 15976269.
- ↑ "Cytokinin dehydrogenase". Protein Data Bank in Europe. https://www.ebi.ac.uk/pdbe/entry/search/index?fq=Cytokinin%20dehydrogenase&submit1=1.
 |  |
