Biology:Chondroitin 6-sulfotransferase
chondroitin 6-sulfotransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.8.2.17 | ||||||||
CAS number | 83589-04-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a chondroitin 6-sulfotransferase (EC 2.8.2.17) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + chondroitin [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and Chondroitin 6-sulfate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase. Other names in common use include chondroitin 6-O-sulfotransferase, 3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate, sulfotransferase, and terminal 6-sulfotransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1.
References
- "Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage". Biochim. Biophys. Acta 717 (3): 414–21. 1982. doi:10.1016/0304-4165(82)90282-3. PMID 6957247.
![]() | Original source: https://en.wikipedia.org/wiki/Chondroitin 6-sulfotransferase.
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