Biology:Citrate CoA-transferase

From HandWiki
Short description: Class of enzymes
citrate CoA-transferase
Identifiers
EC number2.8.3.10
CAS number65187-14-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a citrate CoA-transferase (EC 2.8.3.10) is an enzyme that catalyzes the following chemical reaction:

acetyl-CoA + citrate [math]\displaystyle{ \rightleftharpoons }[/math] acetate + (3S)-citryl-CoA

Thus, the two substrates of this enzyme are acetyl-CoA and citrate, whereas its two products are acetate and (3S)-citryl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acetyl-CoA:citrate CoA-transferase. This enzyme participates in citrate cycle (tca cycle).

References

  • "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate". Eur. J. Biochem. 80 (2): 479–88. 1977. doi:10.1111/j.1432-1033.1977.tb11903.x. PMID 336371.