Biology:Cytosol nonspecific dipeptidase
From HandWiki
| Cytosol nonspecific dipeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.13.18 | ||||||||
| CAS number | 9025-31-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.[1][2][3] This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor.[4] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".[5]
See also
- N-lactoyl-phenylalanine, a chemical compound produced by this enzyme
References
- ↑ "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". The Journal of Biological Chemistry 278 (8): 6521–6531. February 2003. doi:10.1074/jbc.M209764200. PMID 12473676.
- ↑ "Entrez Gene: CNDP2 carnosine dipeptidase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55748.
- ↑ "Cytosol non-specific dipeptidase". Handbook of Proteolytic Enzymes. London: Academic Press. 1998. pp. 1520–1522.
- ↑ "UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens". https://www.uniprot.org/uniprotkb/Q96KP4/entry.
- ↑ "N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids". Proceedings of the National Academy of Sciences of the USA 112 (21): 6601–6606. May 11, 2015. doi:10.1073/pnas.1424638112. PMID 25964343. Bibcode: 2015PNAS..112.6601J.
External links
- Cytosol+non-specific+dipeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
