Biology:Cytosol nonspecific dipeptidase

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Cytosol nonspecific dipeptidase
Identifiers
EC number3.4.13.18
CAS number9025-31-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.[1][2][3] This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor.[4] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".[5]

See also

  • N-lactoyl-phenylalanine, a chemical compound produced by this enzyme

References

  1. "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". The Journal of Biological Chemistry 278 (8): 6521–6531. February 2003. doi:10.1074/jbc.M209764200. PMID 12473676. 
  2. "Entrez Gene: CNDP2 carnosine dipeptidase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55748. 
  3. "Cytosol non-specific dipeptidase". Handbook of Proteolytic Enzymes. London: Academic Press. 1998. pp. 1520–1522. 
  4. "UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens". https://www.uniprot.org/uniprotkb/Q96KP4/entry. 
  5. "N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids". Proceedings of the National Academy of Sciences of the USA 112 (21): 6601–6606. May 11, 2015. doi:10.1073/pnas.1424638112. PMID 25964343. Bibcode2015PNAS..112.6601J. 

External links