Biology:D-alanine—D-serine ligase
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Short description: Class of enzymes
| D-Alanine—D-serine ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.3.2.35 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
D-Alanine—D-serine ligase (EC 6.3.2.35, VanC, VanE, VanG) is an enzyme with systematic name D-alanine:D-serine ligase (ADP-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- D-alanine + D-serine + ATP [math]\displaystyle{ \rightleftharpoons }[/math] D-alanyl-D-serine + ADP + phosphate
The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide.
References
- ↑ "Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance". Gene 112 (1): 53–8. March 1992. doi:10.1016/0378-1119(92)90302-6. PMID 1551598.
- ↑ "Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase". Proceedings of the National Academy of Sciences of the United States of America 94 (19): 10040–4. September 1997. doi:10.1073/pnas.94.19.10040. PMID 9294159. Bibcode: 1997PNAS...9410040P.
- ↑ "VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405". Antimicrobial Agents and Chemotherapy 43 (9): 2161–4. September 1999. doi:10.1128/aac.43.9.2161. PMID 10471558.
- ↑ "The vanG glycopeptide resistance operon from Enterococcus faecalis revisited". Molecular Microbiology 50 (3): 931–48. November 2003. doi:10.1046/j.1365-2958.2003.03737.x. PMID 14617152.
- ↑ "Genetic diversity of the low-level vancomycin resistance gene vanC-2/vanC-3 and identification of a novel vanC subtype (vanC-4) in Enterococcus casseliflavus". Microbial Drug Resistance 15 (1): 1–9. March 2009. doi:10.1089/mdr.2009.0856. PMID 19216682.
External links
- D-alanine—D-serine+ligase at the US National Library of Medicine Medical Subject Headings (MeSH)
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