Biology:Dihydroxy-acid dehydratase

From HandWiki
dihydroxy-acid dehydratase
Identifiers
EC number4.2.1.9
CAS number9024-32-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme dihydroxy-acid dehydratase (EC 4.2.1.9) catalyzes the chemical reaction

2,3-dihydroxy-3-methylbutanoate [math]\displaystyle{ \rightleftharpoons }[/math] 3-methyl-2-oxobutanoate + H2O

This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.

Nomenclature

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include

  • acetohydroxyacid dehydratase,
  • α,β-dihydroxyacid dehydratase,
  • 2,3-dihydroxyisovalerate dehydratase,
  • α,β-dihydroxyisovalerate dehydratase,
  • dihydroxy acid dehydrase,
  • DHAD,
  • and 2,3-dihydroxy-acid hydro-lyase.

References

Further reading

  • "Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves". The Journal of Biological Chemistry 238: 998–1005. Mar 1963. PMID 13962154. 
  • "Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine". The Journal of Biological Chemistry 236: 1414–8. May 1961. PMID 13727223.