Biology:FMN reductase (NADPH)
From HandWiki
Short description: Enzyme involved in redox reactions
| FMN reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.1.38 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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FMN reductase (NADPH) (EC 1.5.1.38, FRP, flavin reductase P, SsuE) is an enzyme with systematic name FMNH2:NADP+ oxidoreductase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction:
- FMNH2 + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] FMN + NADPH + H+
The enzymes from bioluminescent bacteria contain FMN.
References
- ↑ "Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi". European Journal of Biochemistry 57 (2): 461–7. September 1975. doi:10.1111/j.1432-1033.1975.tb02321.x. PMID 1175652. http://www.vliz.be/imisdocs/publications/300066.pdf.
- ↑ "Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi". Biochemistry 16 (13): 2932–6. June 1977. doi:10.1021/bi00632a020. PMID 880288.
- ↑ "Studies of the control of luminescence in Beneckea harveyi: properties of the NADH and NADPH:FMN oxidoreductases". Biochemistry 17 (4): 672–8. February 1978. doi:10.1021/bi00597a018. PMID 23827.
- ↑ "Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme". Journal of Bacteriology 176 (12): 3552–8. June 1994. doi:10.1128/jb.176.12.3552-3558.1994. PMID 8206832.
- ↑ "Flavin reductase P: structure of a dimeric enzyme that reduces flavin". Biochemistry 35 (42): 13531–9. October 1996. doi:10.1021/bi961400v. PMID 8885832.
- ↑ "Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium". Archives of Biochemistry and Biophysics 337 (1): 89–95. January 1997. doi:10.1006/abbi.1996.9746. PMID 8990272.
- ↑ "Mechanism of reduced flavin transfer from Vibrio harveyi NADPH-FMN oxidoreductase to luciferase". Biochemistry 37 (41): 14623–9. October 1998. doi:10.1021/bi981841+. PMID 9772191.
- ↑ "Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli". The Journal of Biological Chemistry 274 (38): 26639–46. September 1999. doi:10.1074/jbc.274.38.26639. PMID 10480865.
External links
- FMN+reductase+(NADPH) at the US National Library of Medicine Medical Subject Headings (MeSH)
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