Biology:Fh8

Short description: Protein from parasite

Fh8 is a small protease produced by the liver fluke Fasciola hepatica. This parasite infects human and animals, and may lead to death. This protease is a very small one, 8 kDa, as is produced and secreted by the parasite during the infection process through liver. This protein has been tested and used as a fusion tag to improve the solubilization and expression of recombinant proteins, due to its biochemical characteristics.

References

• Fraga, H; Faria, TQ; Pinto, F; Almeida, A; Brito, RM; Damas, AM (Dec 2010). "FH8—a small EF-hand protein from Fasciola hepatica". FEBS J 277 (24): 5072–85. doi:10.1111/j.1742-4658.2010.07912.x. PMID 21078120. 
• Silva, E; Castro, A; Lopes, A; Rodrigues, A; Dias, C; Conceição, A; Alonso, J; Correia et al. (Aug 2004). "A recombinant antigen recognized by Fasciola hepatica-infected hosts". J Parasitol 90 (4): 746–51. doi:10.1645/ge-136r. PMID 15357063.