Biology:Germacradienol synthase
From HandWiki
| Germacradienol synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.2.3.22 | ||||||||
| CAS number | 211049-88-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Germacradienol synthase (EC 4.2.3.22, germacradienol/germacrene-D synthase, 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
This enzyme requires Mg2+ for activity.
References
- ↑ "Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis". Proceedings of the National Academy of Sciences of the United States of America 100 (4): 1547–51. February 2003. doi:10.1073/pnas.0337625100. PMID 12556563.
- ↑ "Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2)". Journal of the American Chemical Society 126 (9): 2678–9. March 2004. doi:10.1021/ja039929k. PMID 14995166.
- ↑ "PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin". Proceedings of the National Academy of Sciences of the United States of America 100 (4): 1541–6. February 2003. doi:10.1073/pnas.0337542100. PMID 12563033.
External links
- Germacradienol+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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