Biology:Glutamate—putrescine ligase
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Short description: Class of enzymes
Glutamate-putrescine ligase | |||||||||
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Identifiers | |||||||||
EC number | 6.3.1.11 | ||||||||
CAS number | 914090-78-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a glutamate-putrescine ligase (EC 6.3.1.11) is an enzyme that catalyzes the chemical reaction
- ATP + L-glutamate + putrescine [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate + gamma-L-glutamylputrescine
The 3 substrates of this enzyme are ATP, L-glutamate, and putrescine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamylputrescine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-glutamate:putrescine ligase (ADP-forming). Other names in common use include gamma-glutamylputrescine synthetase, and YcjK. This enzyme participates in urea cycle and metabolism of amino groups.
References
- "A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12". J. Biol. Chem. 280 (6): 4602–8. 2005. doi:10.1074/jbc.M411114200. PMID 15590624.
![]() | Original source: https://en.wikipedia.org/wiki/Glutamate—putrescine ligase.
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