Biology:HBG2
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Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.[1]
Function
The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.[2]
References
- ↑ "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. May 1989. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
- ↑ "Entrez Gene: HBG2 hemoglobin, gamma G". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3048.
Further reading
- "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene.". Prog. Clin. Biol. Res. 191: 125–39. 1985. PMID 2413469.
- "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell. Proteomics 1 (11): 845–67. 2003. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
External links
- Overview of all the structural information available in the PDB for UniProt: P69892 (Hemoglobin subunit gamma-2) at the PDBe-KB.
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