Biology:Hemoglobin subunit zeta

Short description: Mammalian protein found in Homo sapiens

Generic protein structure example

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.

Further reading

• "The multiple functions of hemoglobin". Critical Reviews in Biochemistry and Molecular Biology 30 (3): 165–96. 1995. doi:10.3109/10409239509085142. PMID 7555018. 
• "3' non-coding region sequences in eukaryotic messenger RNA". Nature 263 (5574): 211–4. September 1976. doi:10.1038/263211a0. PMID 822353. Bibcode: 1976Natur.263..211P. 
• "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1)". Nucleic Acids Research 20 (5): 1165. March 1992. doi:10.1093/nar/20.5.1165. PMID 1549498. 
• "End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication". Journal of Molecular Biology 184 (1): 7–21. July 1985. doi:10.1016/0022-2836(85)90039-7. PMID 2411938. 
• "Nucleotide sequences of human globin messenger RNA". Proceedings of the National Academy of Sciences of the United States of America 71 (6): 2300–4. June 1974. doi:10.1073/pnas.71.6.2300. PMID 4135409. Bibcode: 1974PNAS...71.2300M. 
• "Distinctive sequence organization and functional programming of an Alu repeat promoter". Proceedings of the National Academy of Sciences of the United States of America 81 (17): 5291–5. September 1984. doi:10.1073/pnas.81.17.5291. PMID 6089189. Bibcode: 1984PNAS...81.5291P. 
• "Structure of the zeta chain of human embryonic hemoglobin". Proceedings of the National Academy of Sciences of the United States of America 78 (10): 6076–80. October 1981. doi:10.1073/pnas.78.10.6076. PMID 6171809. Bibcode: 1981PNAS...78.6076C. 
• "[Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie 362 (12): 1657–9. December 1981. PMID 6172357. 
• "[Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie 362 (8): 1159–62. August 1981. PMID 6179844. 
• "The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene". Cell 31 (3 Pt 2): 553–63. December 1982. doi:10.1016/0092-8674(82)90311-7. PMID 6297773. 
• "Molecular basis of length polymorphism in the human zeta-globin gene complex". Proceedings of the National Academy of Sciences of the United States of America 80 (16): 5022–6. August 1983. doi:10.1073/pnas.80.16.5022. PMID 6308667. Bibcode: 1983PNAS...80.5022G. 
• "Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA". DNA 1 (4): 355–63. 1983. doi:10.1089/dna.1982.1.355. PMID 6963223. 
• "Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia". Nature 286 (5772): 538–40. July 1980. doi:10.1038/286538a0. PMID 7402334. Bibcode: 1980Natur.286..538O. 
• "The relationship between chromosome structure and function at a human telomeric region". Nature Genetics 15 (3): 252–7. March 1997. doi:10.1038/ng0397-252. PMID 9054936. 
• "Embryonic hemoglobins are expressed in definitive cells". Blood 94 (1): 359–61. July 1999. doi:10.1182/blood.V94.1.359.413a29_359_361. PMID 10381533. 
• "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics 10 (4): 339–52. February 2001. doi:10.1093/hmg/10.4.339. PMID 11157797. 
• "Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures". Prenatal Diagnosis 21 (7): 529–39. July 2001. doi:10.1002/pd.81. PMID 11494285.