Biology:HBQ1
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.[1][2]
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[2]
References
- ↑ "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. May 1989. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
- ↑ 2.0 2.1 "Entrez Gene: HBQ1 hemoglobin, theta 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3049.
Further reading
- "The multiple functions of hemoglobin.". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. 1995. doi:10.3109/10409239509085142. PMID 7555018.
- "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters.". Nucleic Acids Res. 17 (14): 5687–700. 1989. doi:10.1093/nar/17.14.5687. PMID 2569721.
- "Globin gene expression in erythroid human fetal liver cells.". J. Clin. Invest. 83 (3): 1032–8. 1989. doi:10.1172/JCI113944. PMID 2921315.
- "Nucleotide sequence of the human theta 1-globin gene.". Biochem. Genet. 26 (3–4): 207–11. 1988. doi:10.1007/BF00561460. PMID 3408475.
- "Structure and expression of the human theta 1 globin gene". Nature 331 (6151): 94–6. 1988. doi:10.1038/331094a0. PMID 3422341. Bibcode: 1988Natur.331...94H.
- "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. 2001. doi:10.1093/hmg/10.4.339. PMID 11157797.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science 312 (5777): 1215–7. 2006. doi:10.1126/science.1126431. PMID 16728641. Bibcode: 2006Sci...312.1215D.
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