Biology:Homospermidine synthase
From HandWiki
Short description: Enzyme
| Homospermidine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.44 | ||||||||
| CAS number | 76106-84-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Homospermidine synthase (EC 2.5.1.44) is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (1) 2 putrescine [math]\displaystyle{ \rightleftharpoons }[/math] sym-homospermidine + NH3 + H+
- (2) putrescine + spermidine [math]\displaystyle{ \rightleftharpoons }[/math] sym-homospermidine + propane-1,3-diamine
The reaction of this enzyme occurs in three steps.
References
- ↑ "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis [proceedings]". Biochemical Society Transactions 7 (1): 199–201. February 1979. doi:10.1042/bst0070199. PMID 437275.
- ↑ "Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation". Can. J. Chem. 72: 80–85. 1994. doi:10.1139/v94-013.
- ↑ "Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105". Journal of Biochemistry 114 (1): 45–9. July 1993. doi:10.1093/oxfordjournals.jbchem.a124137. PMID 8407874.
- ↑ "Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings". The Biochemical Journal 190 (2): 461–4. August 1980. doi:10.1042/bj1900461. PMID 7470060.
- ↑ "Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli". J. Gen. Appl. Microbiol. 42 (5): 411–419. 1996. doi:10.2323/jgam.42.411.
- ↑ "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 14777–82. December 1999. doi:10.1073/pnas.96.26.14777. PMID 10611289. Bibcode: 1999PNAS...9614777O.
External links
- Homospermidine+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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