Biology:Homospermidine synthase (spermidine-specific)
From HandWiki
Short description: Class of enzymes
| homospermidine synthase (spermidine-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.45 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a homospermidine synthase (spermidine-specific) (EC 2.5.1.45) is an enzyme that catalyzes the chemical reaction
- spermidine + putrescine [math]\displaystyle{ \rightleftharpoons }[/math] sym-homospermidine + propane-1,3-diamine
Thus, the two substrates of this enzyme are spermidine and putrescine, whereas its two products are sym-homospermidine and propane-1,3-diamine.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming).
References
- "Comparative anatomical study of internal brooding in three anascan bryozoans (Cheilostomata) and its taxonomic and evolutionary implications". J. Morphol. 267 (6): 739–49. 2006. doi:10.1002/jmor.10438. PMID 16526057.
- "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14777–82. 1999. doi:10.1073/pnas.96.26.14777. PMID 10611289.
- "Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision". Phytochemistry 55 (4): 311–316. 2000. doi:10.1016/S0031-9422(00)00267-3. PMID 11117877.
 |  |
