Biology:Human betaherpesvirus 6A

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Short description: Species of virus


Human betaherpesvirus 6A
Virus classification e
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Orthoherpesviridae
Genus: Roseolovirus
Species:
Human betaherpesvirus 6A
Synonyms

Human herpesvirus 6

Human betaherpesvirus 6A (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]

HHV-6A and infertility

  • A 2016 study showed that 43% of women with unexplained infertility tested positive for HHV-6A while 0% of women in the fertile control group tested positive. HHV-6A was found present in endrometrial epithelial cells from women with unexplained infertility. [2]
  • A 2018 study reports the prevalence of HHV-6A in endometrial biopsies among women experiencing recurrent implantation failure after IVF/ET compared to control groups.[3]
  • A 2019 study confirmed the presence of HHV-6A infection in 40% of idiopathic infertile women. Identifying the effect of HHV-6A infection on endometrial immune status opens up a new perspectives on ferility care. Its possible to choose antiviral therapies and non-hormonal approaches for women with unexplained infertility characterized by HHV-6A to increase their pregnancy rate.[4]

Taxonomy

In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions,[5] and growth patterns.[6] In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses and named Human betaherpesvirus 6A and Human betaherpesvirus 6B.[7] Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts.

Pathology

Human betaherpesvirus 6A affects humans and includes several adult-derived strains. Its disease spectrum is not well defined, although it is thought by some to be more neurovirulent than Human betaherpesvirus 6B.[8][9]

References

  1. ↑ "ICTV Master Species List 2018b.v2". https://talk.ictvonline.org/files/master-species-lists/m/msl/8266. 
  2. ↑ "Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility". PLOS ONE 11 (7): e0158304. 2016-07-01. doi:10.1371/journal.pone.0158304. PMID 27367597. Bibcode: 2016PLoSO..1158304M. 
  3. ↑ "Prevalence of HHV-6 in endometrium from women with recurrent implantation failure". American Journal of Reproductive Immunology 80 (1): e12862. July 2018. doi:10.1111/aji.12862. PMID 29667291. 
  4. ↑ "HHV-6A infection of endometrial epithelial cells affects immune profile and trophoblast invasion". American Journal of Reproductive Immunology 82 (4): e13174. October 2019. doi:10.1111/aji.13174. PMID 31338899. 
  5. ↑ "Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry". Journal of Virology 85 (24): 12962–12971. December 2011. doi:10.1128/JVI.05622-11. PMID 21957287. 
  6. ↑ "Human herpesvirus 6". Clinical Microbiology Reviews 10 (3): 521–567. July 1997. doi:10.1128/CMR.10.3.521. PMID 9227865. 
  7. ↑ "Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012)". Archives of Virology 157 (7): 1411–1422. July 2012. doi:10.1007/s00705-012-1299-6. PMID 22481600. 
  8. ↑ "The roles of viruses in brain tumor initiation and oncomodulation". Journal of Neuro-Oncology 105 (3): 451–466. December 2011. doi:10.1007/s11060-011-0658-6. PMID 21720806. 
  9. ↑ "The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro". Proceedings of the National Academy of Sciences of the United States of America 107 (12): 5563–5568. March 2010. doi:10.1073/pnas.0913586107. PMID 20212114. Bibcode: 2010PNAS..107.5563A. 


Wikidata ☰ Q24808739 entry



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