Biology:Macavirus
Macavirus is a genus of viruses in the order Herpesvirales, in the family Orthoherpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are nine species in this genus. Diseases associated with this genus include: inapparent infection in their reservoir hosts (wildebeest for alHV-1 and sheep for ovHV-2), but fatal lymphoproliferative disease when they infect MCF-susceptible hosts, including cattle, deer, bison, water buffalo and pigs.[1][2]
Species
The genus contains the following species, listed by scientific name and followed by the common name of the species:[2][3]
- Macavirus alcelaphinegamma1, Alcelaphine herpesvirus 1
- Macavirus alcelaphinegamma2, Alcelaphine herpesvirus 2
- Macavirus bovinegamma6, Bovine herpesvirus 6
- Macavirus caprinegamma2, Caprine herpesvirus 2
- Macavirus hippotraginegamma1, Hippotragine herpesvirus 1
- Macavirus ovinegamma2, Ovine herpesvirus 2
- Macavirus suidgamma3, Porcine lymphotropic herpesvirus 1
- Macavirus suidgamma4, Porcine lymphotropic herpesvirus 2
- Macavirus suidgamma5, Porcine lymphotropic herpesvirus 3
Structure
Viruses in Macavirus are enveloped, with icosahedral, spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 180kb in length.[1]
| Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
|---|---|---|---|---|---|
| Macavirus | Spherical pleomorphic | T=16 | Enveloped | Linear | Monopartite |
Life cycle
Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. Dna templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding. Mammals serve as the natural host.[1]
| Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
|---|---|---|---|---|---|---|---|
| Macavirus | Mammals | B-lymphocytes | Glycoprotiens | Budding | Nucleus | Nucleus | Sex; saliva |
References
- ↑ 1.0 1.1 1.2 "Viral Zone". ExPASy. http://viralzone.expasy.org/all_by_species/526.html.
- ↑ 2.0 2.1 "Virus Taxonomy: 2023 Release". International Committee on Taxonomy of Viruses. 30 October 2024. https://ictv.global/taxonomy.
- ↑ "Species List: Orthoherpesviridae". International Committee on Taxonomy of Viruses. https://ictv.global/report/chapter/orthoherpesviridae/taxonomy/orthoherpesviridae.
External links
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Wikispecies has information related to Macavirus |
Colour indicates non-mammalian host: mollusc • frog • fish • bird • reptile –– Incertae sedis species listed below (sub)family –– Source: ICTV ––  Commons •  Wikispecies |
Wikidata ☰ Q18813549 entry
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