Biology:Hydroxymandelonitrile lyase
From HandWiki
| hydroxymandelonitrile lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.2.11 | ||||||||
| CAS number | 9075-38-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme hydroxymandelonitrile lyase (EC 4.1.2.11) catalyzes the chemical reaction
- (S)-4-hydroxymandelonitrile [math]\displaystyle{ \rightleftharpoons }[/math] cyanide + 4-hydroxybenzaldehyde
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming). Other names in common use include hydroxynitrile lyase, oxynitrilase, Sorghum hydroxynitrile lyase, and (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase. This enzyme participates in cyanoamino acid metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GXS.
References
- AJ; Shaw, PJ; Nath, CE; Yadav, SP; Stephen, KR; Earl, JW; McLachlan, AJ (2006). "Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases". Antimicrob. Agents Chemother. 50 (3): 935–42. doi:10.1128/AAC.50.3.935-942.2006. PMID 16495254.
- "The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin". J. Biol. Chem. 241 (19): 4457–62. 1966. PMID 5922969.
 |  |
