Biology:Leucoanthocyanidin reductase
From HandWiki
| Leucoanthocyanidin reductase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.17.1.3 | ||||||||
| CAS number | 93389-48-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a leucoanthocyanidin reductase (EC 1.17.1.3) (LAR, aka leucocyanidin reductase or LCR) is an enzyme that catalyzes the chemical reaction
- (2R,3S)-catechin + NADP+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
The 3 substrates of this enzyme are (2R,3S)-catechin, NADP+, and H2O, whereas its 3 products are 2,3-trans-3,4-cis-leucocyanidin, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (2R,3S)-catechin:NADP+ 4-oxidoreductase. This enzyme is also called leucocyanidin reductase. This enzyme participates in flavonoid biosynthesis.
The enzyme can be found in the plant Hedysarum sulphurescens and in Vitis vinifera (grape).[1]
References
- ↑ "Crystal Structure and Catalytic Mechanism of Leucoanthocyanidin Reductase from Vitis vinifera". J. Mol. Biol. 397 (4): 1079–91. April 2010. doi:10.1016/j.jmb.2010.02.002. PMID 20138891.
Further reading
- "Synthesis of 3,4-cis-[3H]leucocyanidin and enzymatic reduction to catechin". Anal. Biochem. 209 (2): 274–7. 1993. doi:10.1006/abio.1993.1119. PMID 8470799.
- "Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA". J. Biol. Chem. 278 (34): 31647–56. 2003. doi:10.1074/jbc.M302783200. PMID 12788945.
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