Biology:MIR95

MicroRNA 95 is a small non-coding RNA that in humans is encoded by the MIR95 gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• Mourelatos, Z; Dostie, J; Paushkin, S; Sharma, A; Charroux, B; Abel, L; Rappsilber, J; Mann, M et al. (2002). "MiRNPs: A novel class of ribonucleoproteins containing numerous microRNAs". Genes & Development 16 (6): 720–8. doi:10.1101/gad.974702. PMID 11914277. 
• Li, W. G.; Yuan, Y. Z.; Qiao, M. M.; Zhang, Y. P. (2012). "High dose glargine alters the expression profiles of microRNAs in pancreatic cancer cells". World Journal of Gastroenterology 18 (21): 2630–9. doi:10.3748/wjg.v18.i21.2630. PMID 22690071. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.