Biology:Mir-675 microRNA precursor family
| mir-675 | |
|---|---|
| Identifiers | |
| Symbol | mir-675 |
| Rfam | RF00897 |
| miRBase family | MIPF0000365 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-675 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Inhibition of cell proliferation
miR-675 overexpression brings about reduced proliferation in a range of embryonic and extraembryonic stem cell lines. It has been found to be embedded in the first exon of the large intergenic non-coding RNA H19, which is responsible for limiting placental growth prior to birth. There is upregulation of the targets of miR-675 in placentas lacking H19; these include the insulin-like growth factor 1 receptor (IGF1R). Thus placentas lacking miR-675 continue to grow. It is possible that controlled miR-675 release from H19 may enable a rapid inhibition of cell proliferation in response to cellular stress or oncogenic signals.[1]
COL2A1 upregulation in Osteoarthritis
miR-675 has been found to be upregulated in osteoarthritic cartilage, alongside H19.[2] Indeed, there is co-regulation of these two RNAs. The COL2A1 gene associated with osteoarthritis through altered expression levels compared with in normal tissue is upregulated by miR-675 overexpression. It has been proposed that miR-675 may modulate collagen type II levels via an unknown target molecule, and there is potential for a diagnostic metabolic balance indicator in osteoarthritis through this microRNA.
See also
References
- ↑ "The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r". Nature Cell Biology 14 (7): 659–65. June 2012. doi:10.1038/ncb2521. PMID 22684254.
- ↑ "Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions". Journal of Molecular Medicine 90 (10): 1185–95. October 2012. doi:10.1007/s00109-012-0895-y. PMID 22527881. https://pubmed.ncbi.nlm.nih.gov/22527881.
Further reading
- Lo, Kwok-Wai, ed (2012). "Upregulation of miR-31* is negatively associated with recurrent/newly formed oral leukoplakia". PLOS ONE 7 (6): e38648. doi:10.1371/journal.pone.0038648. PMID 22719913. Bibcode: 2012PLoSO...738648X.
- "MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers". The Journal of Allergy and Clinical Immunology 129 (4): 1064–75.e9. April 2012. doi:10.1016/j.jaci.2012.01.060. PMID 22391115.
- "Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)". The Journal of Biological Chemistry 287 (2): 916–24. January 2012. doi:10.1074/jbc.M111.302430. PMID 22102413.
- "Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours". Journal of Clinical Pathology 64 (6): 529–35. June 2011. doi:10.1136/jcp.2010.085621. PMID 21471143.
- "Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes". The Journal of Biological Chemistry 285 (32): 24381–7. August 2010. doi:10.1074/jbc.M110.111328. PMID 20529846.
- "Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer". Carcinogenesis 31 (3): 350–8. March 2010. doi:10.1093/carcin/bgp181. PMID 19926638.
- "Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians". Nature Genetics 40 (8): 971–6. August 2008. doi:10.1038/ng.168. PMID 18587395.
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