Biology:N1-acetylpolyamine oxidase
From HandWiki
| N1-acetylpolyamine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.3.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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N1-acetylpolyamine oxidase (EC 1.5.3.13, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) N1-acetylspermidine + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] putrescine + 3-acetamidopropanal + H2O2
- (2) N1-acetylspermine + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] spermidine + 3-acetamidopropanal + H2O2
This enzyme also catalyses the reaction:
- N1,N12-diacetylspermine + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] N1-acetylspermidine + 3-acetamamidopropanal + H2O2.
References
- ↑ "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion". The Biochemical Journal 370 (Pt 1): 19–28. February 2003. doi:10.1042/BJ20021779. PMID 12477380.
- ↑ "Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines". The Journal of Biological Chemistry 280 (8): 6595–601. February 2005. doi:10.1074/jbc.M412788200. PMID 15611107.
- ↑ "Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity". Cancer Chemotherapy and Pharmacology 56 (1): 83–90. July 2005. doi:10.1007/s00280-004-0936-5. PMID 15791459.
- ↑ "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase". The Journal of Biological Chemistry 278 (23): 20514–25. June 2003. doi:10.1074/jbc.M302149200. PMID 12660232.
External links
- N1-acetylpolyamine+oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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