Biology:NCK2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene.[1][2][3]

Function

NCK belongs to family of adaptor proteins. There are two mammalian NCK genes, NCK1 and NCK2. NCK1 is located in chromosome 3 and NCK2 is located in chromosome 2. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Interactions

NCK2 has been shown to interact with:


References

  1. 1.0 1.1 1.2 "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". The Journal of Biological Chemistry 273 (39): 25171–8. Sep 1998. doi:10.1074/jbc.273.39.25171. PMID 9737977. 
  2. "Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins". Biochemistry 45 (23): 7171–84. Jun 2006. doi:10.1021/bi060091y. PMID 16752908. 
  3. 3.0 3.1 "Entrez Gene: NCK2 NCK adaptor protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8440. 
  4. 4.0 4.1 "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways". Molecular Biology of the Cell 9 (12): 3367–82. Dec 1998. doi:10.1091/mbc.9.12.3367. PMID 9843575. 
  5. 5.0 5.1 "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". The Journal of Biological Chemistry 274 (9): 5542–9. Feb 1999. doi:10.1074/jbc.274.9.5542. PMID 10026169. 
  6. "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Molecular and Cellular Biology 19 (3): 2425–34. Mar 1999. doi:10.1128/mcb.19.3.2425. PMID 10022929. 
  7. "Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb". Molecular and Cellular Biology 20 (21): 7867–80. Nov 2000. doi:10.1128/mcb.20.21.7867-7880.2000. PMID 11027258. 
  8. "Nck-2 interacts with focal adhesion kinase and modulates cell motility". The International Journal of Biochemistry & Cell Biology 34 (7): 791–805. Jul 2002. doi:10.1016/s1357-2725(02)00002-x. PMID 11950595. 
  9. "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell 109 (7): 901–12. Jun 2002. doi:10.1016/S0092-8674(02)00799-7. PMID 12110186. 
  10. "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochemical and Biophysical Research Communications 294 (5): 1087–92. Jun 2002. doi:10.1016/S0006-291X(02)00606-X. PMID 12074588. 

Further reading

External links