Biology:Neoabietadiene synthase
From HandWiki
Short description: Enzyme
| Neoabietadiene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.132 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Neoabietadiene synthase (EC 4.2.3.132, AgAS, PtTPS-LAS) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming).[1][2][3] This enzyme catalyses the following chemical reaction:
- (+)-copalyl diphosphate neoabietadiene + diphosphate
This enzyme is isolated from Abies grandis (grand fir).
References
- ↑ "Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme". Biochemistry 39 (50): 15592–15602. 2000. doi:10.1021/bi001997l. PMID 11112547.
- ↑ "Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis". The Journal of Biological Chemistry 287 (9): 6840–50. February 2012. doi:10.1074/jbc.M111.337592. PMID 22219188.
- ↑ "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry 67 (15): 1572–8. August 2006. doi:10.1016/j.phytochem.2006.01.011. PMID 16497345.
External links
- Neoabietadiene+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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