Biology:PDSS2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene.

Function

The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis.

Clinical significance

It may be associated with Coenzyme Q10 deficiency.

See also

• PDSS1

Further reading

• "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121. 
• "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M. 
• "COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement.". J. Am. Soc. Nephrol. 18 (10): 2773–80. 2007. doi:10.1681/ASN.2006080833. PMID 17855635. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecular weight complex.". FEBS Lett. 584 (4): 652–6. 2010. doi:10.1016/j.febslet.2009.12.029. PMID 20051244. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.". FEBS J. 272 (21): 5606–22. 2005. doi:10.1111/j.1742-4658.2005.04956.x. PMID 16262699. 
• "Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome.". J. Am. Soc. Nephrol. 21 (7): 1209–17. 2010. doi:10.1681/ASN.2009121309. PMID 20507940. 
• "Anticancer activity of PDSS2, prenyl diphosphate synthase, subunit 2, in gastric cancer tissue and the SGC7901 cell line.". Anticancer Drugs 20 (2): 141–8. 2009. doi:10.1097/CAD.0b013e32832016a9. PMID 19209031. 
• "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.". PLOS ONE 5 (9): e12862. 2010. doi:10.1371/journal.pone.0012862. PMID 20877624. Bibcode: 2010PLoSO...512862H. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.". Genet. Med. 10 (9): 668–74. 2008. doi:10.1097/GIM.0b013e3181833793. PMID 18978678. 
• "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. 2010. doi:10.2337/dc10-0452. PMID 20628086. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.