Biology:Phthalate 4,5-cis-dihydrodiol dehydrogenase
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Short description: Class of enzymes
| phthalate 4,5-cis-dihydrodiol dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.3.1.64 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phthalate 4,5-cis-dihydrodiol dehydrogenase (EC 1.3.1.64) is an enzyme that catalyzes the chemical reaction
- cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 4,5-dihydroxyphthalate + NADH + H+
Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate and NAD+, whereas its 3 products are 4,5-dihydroxyphthalate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase. This enzyme participates in 2,4-dichlorobenzoate degradation.
References
- "Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia". J. Biol. Chem. 262 (4): 1510–8. 1987. PMID 3805038.
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