Biology:RAD23A

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.

Function

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

Interactions

RAD23A has been shown to interact with:

• Ataxin 3,
• PSMD4, and
• Sequestosome 1.

Further reading

• "Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera". J. Autoimmun. 7 (2): 243–261. 1994. doi:10.1006/jaut.1994.1019. PMID 8037842. 
• "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23". EMBO J. 13 (8): 1831–43. 1994. doi:10.1002/j.1460-2075.1994.tb06452.x. PMID 8168482. 
• "XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes". Nucleic Acids Res. 24 (13): 2551–2559. 1996. doi:10.1093/nar/24.13.2551. PMID 8692695. 
• "Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23". Genomics 31 (1): 20–27. 1996. doi:10.1006/geno.1996.0004. PMID 8808275. http://repub.eur.nl/pub/3097. 
• "XPC interacts with both HHR23B and HHR23A in vivo". Mutat. Res. 383 (3): 197–203. 1997. doi:10.1016/s0921-8777(97)00002-5. PMID 9164480. 
• "Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair". J. Virol. 71 (12): 9732–42. 1997. doi:10.1128/JVI.71.12.9732-9742.1997. PMID 9371639. 
• "Rad23 links DNA repair to the ubiquitin/proteasome pathway". Nature 391 (6668): 715–718. 1998. doi:10.1038/35661. PMID 9490418. Bibcode: 1998Natur.391..715S. 
• "HHR23A, the human homologue of the yeast repair protein RAD23, interacts specifically with Vpr protein and prevents cell cycle arrest but not the transcriptional effects of Vpr". Virology 245 (2): 323–330. 1998. doi:10.1006/viro.1998.9138. PMID 9636371. 
• "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr". Nat. Struct. Biol. 5 (12): 1042–1047. 1998. doi:10.1038/4220. PMID 9846873. 
• "Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination". J. Biol. Chem. 274 (26): 18785–18792. 1999. doi:10.1074/jbc.274.26.18785. PMID 10373495. 
• "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. 274 (39): 28019–28025. 1999. doi:10.1074/jbc.274.39.28019. PMID 10488153. 
• "3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins". J. Biol. Chem. 275 (37): 28433–28438. 2000. doi:10.1074/jbc.M001064200. PMID 10854423. 
• "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. 9 (12): 1795–1803. 2000. doi:10.1093/hmg/9.12.1795. PMID 10915768. 
• "Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr". Biochemistry 39 (46): 14103–14112. 2001. doi:10.1021/bi0017071. PMID 11087358. 
• "Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53". Cancer Res. 61 (1): 64–70. 2001. PMID 11196199. 
• "Interaction of human immunodeficiency virus type 1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr". Virology 282 (1): 176–185. 2001. doi:10.1006/viro.2000.0791. PMID 11259200. 
• "Analysis of apoptosis induced by HIV-1 Vpr and examination of the possible role of the hHR23A protein". Exp. Cell Res. 267 (2): 243–257. 2001. doi:10.1006/excr.2001.5247. PMID 11426943. 
• "Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly". EMBO Rep. 2 (10): 933–938. 2002. doi:10.1093/embo-reports/kve203. PMID 11571271. 
• "Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination". Nucleic Acids Res. 30 (2): 581–591. 2002. doi:10.1093/nar/30.2.581. PMID 11788722.