Biology:SOS box
From HandWiki
SOS box is the region in the promoter of various genes to which the LexA repressor binds to repress the transcription of SOS-induced proteins. This occurs in the absence of DNA damage. In the presence of DNA damage the binding of LexA is inactivated by the RecA activator. SOS boxes differ in DNA sequences and binding affinity towards LexA from organism to organism.[1] Furthermore, SOS boxes may be present in a dual fashion, which indicates that more than one SOS box can be within the same promoter.[2]
Examples
| Phylogenetic Clade | Sequence | Reference |
|---|---|---|
| Alphaproteobacteria | GAAC(N)7GAAC GTTC(N)7GTTC |
[3][4] |
| Betaproteobacteria Gammaproteobacteria |
CTGT(N)8ACAG | [5] |
| Deltaproteobacteria | CTRHAMRYBYGTTCAGS | [6] |
| Gram-positive bacteria | CGAACRNRYGTTYC | [7][8] |
| Cyanobacteria | RGTAC(N)3DGTWCB | [9] |
See Nucleic acid nomenclature for an explanation of non-GATC nucleotide letters.
See also
- SOS response
- SOS gene
- LexA
- RecA
References
- ↑ Walker, GC (October 1995). "SOS-regulated proteins in translesion DNA synthesis and mutagenesis.". Trends in Biochemical Sciences 20 (10): 416–20. doi:10.1016/s0968-0004(00)89091-x. PMID 8533155.
- ↑ Gillor, Osnat; Vriezen, Jan A. C.; Riley, Margaret A. (Jun 2008). "The role of SOS boxes in enteric bacteriocin regulation". Microbiology 154 (6): 1783–1792. doi:10.1099/mic.0.2007/016139-0. PMID 18524933.
- ↑ "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. June 1998. doi:10.1046/j.1365-2958.1998.00860.x. PMID 9663685.
- ↑ "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. August 1999. doi:10.1007/s004380051066. PMID 10503543.
- ↑ "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics 19 (17): 2225–36. November 2003. doi:10.1093/bioinformatics/btg303. PMID 14630651.
- ↑ "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. August 2003. doi:10.1046/j.1365-2958.2003.03592.x. PMID 12864858.
- ↑ "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. 15 April 1998. doi:10.1128/JB.180.8.2201-2211.1998. PMID 9555905.
- ↑ "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. June 2002. doi:10.1128/JB.184.12.3287-3295.2002. PMID 12029045.
- ↑ "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics 271 (1): 40–9. February 2004. doi:10.1007/s00438-003-0952-x. PMID 14652736.
- "Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics". Nucleic Acids Research 32 (22): 6617–26. 2004. doi:10.1093/nar/gkh996. PMID 15604457.
- Shinagawa H (1996). "SOS response as an adaptive response to DNA damage in prokaryotes". Stress-Inducible Cellular Responses. 77. 221–35. doi:10.1007/978-3-0348-9088-5_14. ISBN 978-3-0348-9901-7.
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