Biology:rRNA (adenosine-2'-O-)-methyltransferase
From HandWiki
| rRNA (adenosine-2'-O-)-methyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.1.1.66 | ||||||||
| CAS number | 80146-87-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a rRNA (adenosine-2'-O-)-methyltransferase (EC 2.1.1.66) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + rRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine
Thus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing a single residue of 2'-O-methyladenosine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase. Other names in common use include ribosomal ribonucleate adenosine 2'-methyltransferase, rRNA adenosine 2'-methylase, RNA-pentose methylase, and thiostrepton-resistance methylase.
References
- Thompson J; Cundliffe E (1981). "Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton". J. Gen. Microbiol. 124: 291–297. doi:10.1099/00221287-124-2-291.
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