Biology:Squalene—-hopanol cyclase
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Squalene—hopanol cyclase | |||||||||
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Identifiers | |||||||||
EC number | 4.2.1.129 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Squalene—hopanol cyclase (EC 4.2.1.129, squalene—hopene cyclase) is an enzyme with systematic name hopan-22-ol hydro-lyase.[1][2] This enzyme catalyses the following chemical reaction
- hopan-22-ol [math]\displaystyle{ \rightleftharpoons }[/math] squalene + H2O
The enzyme produces the cyclization products hopene and hopanol.
References
- ↑ "Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring". Organic & Biomolecular Chemistry 2 (10): 1456–70. May 2004. doi:10.1039/b401172d. PMID 15136801.
- ↑ "Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius". Bioscience, Biotechnology, and Biochemistry 68 (3): 728–38. March 2004. doi:10.1271/bbb.68.728. PMID 15056909.
External links
- Squalene---hopanol+cyclase at the US National Library of Medicine Medical Subject Headings (MeSH)
![]() | Original source: https://en.wikipedia.org/wiki/Squalene—-hopanol cyclase.
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