Biology:tRNA-pseudouridine synthase I

From HandWiki
tRNA-pseudouridine synthase
Identifiers
EC number5.4.99.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a tRNA-pseudouridine synthase I (EC 5.4.99.12) is an enzyme that catalyzes the chemical reaction

tRNA uridine [math]\displaystyle{ \rightleftharpoons }[/math] tRNA pseudouridine

Hence, this enzyme has one substrate, tRNA uridine, and one product, tRNA pseudouridine.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is tRNA-uridine uracilmutase. Other names in common use include tRNA-uridine isomerase, tRNA pseudouridylate synthase I, transfer ribonucleate pseudouridine synthetase, pseudouridine synthase, and transfer RNA pseudouridine synthetase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1VS3, 2NQP, 2NR0, and 2NRE.

References