Biology:TRNA pseudouridine32 synthase
From HandWiki
| tRNA pseudouridine32 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.28 | ||||||||
| CAS number | 430429-15-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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tRNA pseudouridine32 synthase (EC 5.4.99.28, RluA, pseudouridine synthase RluA, Pus9p, Rib2/Pus8p) is an enzyme with systematic name tRNA-uridine32 uracil mutase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- tRNA uridine32 [math]\displaystyle{ \rightleftharpoons }[/math] tRNA pseudouridine32
The dual enzyme from Escherichia coli also catalyses the formation of pseudouridine746 in 23S rRNA.
References
- ↑ "Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure". Molecular Cell 24 (4): 535–45. November 2006. doi:10.1016/j.molcel.2006.09.017. PMID 17188032.
- ↑ "Functional importance of motif I of pseudouridine synthases: mutagenesis of aligned lysine and proline residues". Biochemistry 39 (31): 9459–65. August 2000. doi:10.1021/bi001079n. PMID 10924141.
- ↑ "Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA". The Journal of Biological Chemistry 274 (27): 18880–6. July 1999. doi:10.1074/jbc.274.27.18880. PMID 10383384.
- ↑ "Role of cysteine residues in pseudouridine synthases of different families". Biochemistry 38 (40): 13106–11. October 1999. doi:10.1021/bi9913911. PMID 10529181.
- ↑ "A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe)". RNA 1 (4): 437–48. June 1995. PMID 7493321.
- ↑ "Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae". The Journal of Biological Chemistry 279 (51): 52998–3006. December 2004. doi:10.1074/jbc.m409581200. PMID 15466869. https://hal.univ-lorraine.fr/hal-01738505/file/Behm-Ansmant%20et%20al.%2C%202004%2C%20JBC%2C%20Pus8_9.pdf.
External links
- TRNA+pseudouridine32+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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