Biology:TRNA pseudouridine55 synthase
From HandWiki
| tRNA pseudouridine55 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.25 | ||||||||
| CAS number | 430429-15-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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tRNA pseudouridine55 synthase (EC 5.4.99.25, TruB, aCbf5, Pus4, YNL292w (gene), Psi55 tRNA pseudouridine synthase, tRNA:Psi55-synthase, tRNA pseudouridine 55 synthase, tRNA:pseudouridine-55 synthase, Psi55 synthase, tRNA Psi55 synthase, tRNA:Psi55 synthase, tRNA-uridine55 uracil mutase, Pus10, tRNA-uridine54/55 uracil mutase) is an enzyme with systematic name tRNA-uridine55 uracil mutase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- tRNA uridine55 [math]\displaystyle{ \rightleftharpoons }[/math] tRNA pseudouridine55
Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules.
References
- ↑ "Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli". RNA 1 (1): 102–12. March 1995. PMID 7489483.
- ↑ "The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs". Nucleic Acids Research 25 (22): 4493–9. November 1997. doi:10.1093/nar/25.22.4493. PMID 9358157.
- ↑ "A cell-free yellow lupin extract containing activities of pseudouridine 35 and 55 synthases". Acta Biochimica Polonica 45 (3): 745–54. 1998. doi:10.18388/abp.1998_4268. PMID 9918501.
- ↑ "Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft". The Journal of Biological Chemistry 279 (23): 24585–91. June 2004. doi:10.1074/jbc.m401045200. PMID 15028724.
- ↑ "Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain". Protein Science 14 (8): 2201–6. August 2005. doi:10.1110/ps.051493605. PMID 15987897.
- ↑ "Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA". RNA 14 (12): 2521–7. December 2008. doi:10.1261/rna.1276508. PMID 18952823.
External links
- TRNA+pseudouridine55+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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