Biology:Thiol S-methyltransferase
From HandWiki
thiol S-methyltransferase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC number | 2.1.1.9 | ||||||||
CAS number | 9029-81-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, a thiol S-methyltransferase (EC 2.1.1.9) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + a thiol [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + a thioether
Thus, the two substrates of this enzyme are S-adenosyl methionine and thiol, whereas its two products are S-adenosylhomocysteine and thioether.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:thiol S-methyltransferase. Other names in common use include S-methyltransferase, thiol methyltransferase, and TMT. This enzyme participates in selenoamino acid metabolism.
References
- "Purification and characterization of rat liver microsomal thiol methyltransferase". Biochim. Biophys. Acta 522 (2): 340–53. 1978. doi:10.1016/0005-2744(78)90068-2. PMID 623768.
- Bremer J; Greenberg DM (1961). "Enzymic methylation of foreign sulfhydryl compounds". Biochim. Biophys. Acta 46 (2): 217–224. doi:10.1016/0006-3002(61)90746-6.
- "Thiol S-methyltransferase from rat liver". Arch. Biochem. Biophys. 196 (2): 631–7. 1979. doi:10.1016/0003-9861(79)90317-5. PMID 485170.
![]() | Original source: https://en.wikipedia.org/wiki/Thiol S-methyltransferase.
Read more |