Biology:UCHL3
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Short description: Human gene and enzyme
 Generic protein structure example |
Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.[1][2]
Interactions
UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.[3][4]
See also
- Ubiquitin carboxy-terminal hydrolase L1—an enzyme
References
- ↑ "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science 246 (4930): 670–3. Dec 1989. doi:10.1126/science.2530630. PMID 2530630. Bibcode: 1989Sci...246..670W.
- ↑ "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7347.
- ↑ "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett 585 (16): 2568–74. July 2011. doi:10.1016/j.febslet.2011.06.037. PMID 21762696.
- ↑ "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. October 1998. doi:10.1006/bbrc.1998.9532. PMID 9790970.
Further reading
- "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution.". EMBO J. 16 (13): 3787–96. 1997. doi:10.1093/emboj/16.13.3787. PMID 9233788.
- "The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3.". J. Mol. Biol. 291 (5): 1067–77. 1999. doi:10.1006/jmbi.1999.3038. PMID 10518943.
- "Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution.". Biochem. Biophys. Res. Commun. 264 (1): 235–40. 1999. doi:10.1006/bbrc.1999.1492. PMID 10527871.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.". J. Hum. Genet. 48 (5): 249–70. 2003. doi:10.1007/s10038-003-0021-7. PMID 12721789.
- "Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.". Proteomics 3 (11): 2108–15. 2004. doi:10.1002/pmic.200300594. PMID 14595809.
- "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. 2004. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.". J. Biol. Chem. 280 (2): 1512–20. 2005. doi:10.1074/jbc.M410770200. PMID 15531586.
- "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.". Mol. Carcinog. 45 (4): 260–9. 2006. doi:10.1002/mc.20177. PMID 16402389.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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