Biology:UDP-N-acetylglucosamine enolpyruvyl transferase

From HandWiki

UDP-N-acetylglucosamine enolpyruvyl transferase (or MurA) is an enzyme[1] that catalyzes the first committed step in peptidoglycan biosynthesis, namely the ligation of phosphoenolpyruvate (PEP) to the 3'-hydroxyl group of UDP-N-acetylglucosamine. This pyruvate moiety provides the linker that bridges the glycan and peptide portion of peptidoglycan.[2] The enzyme is inhibited by the antibiotic fosfomycin, which covalently modifies an active site cysteine residue.[3]

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