Chemistry:3-Methyl-PCPy

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Short description: Chemical compound
3-Me-PCPy
3-Me-PCPy Structure.svg
Clinical data
ATC code
  • None
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC17H25N
Molar mass243.394 g·mol−1
3D model (JSmol)

3-Methyl-PCPy (3-Me-PCPy) is an arylcyclohexylamine derivative with an unusual spectrum of pharmacological effects, acting as both a potent NMDA antagonist and also a triple reuptake inhibitor which inhibits reuptake of all three monoamine neurotransmitters serotonin, dopamine and noradrenaline. It also acts as a high affinity sigma receptor ligand, selective for the σ2 subtype. It produces both stimulant and dissociative effects in animal behavioural studies.[1][2][3]

Legal Status

3-Methyl-PCPy is covered by drug analogue laws in various jurisdictions (UK, Germany, Japan, Australia etc.) as a generic arylcyclohexylamine derivative, and a structural isomer of phencyclidine.

See also

References

  1. "Preparation and analytical characterization of 1-(1-phenylcyclohexyl)piperidine (PCP) and 1-(1-phenylcyclohexyl)pyrrolidine (PCPy) analogues". Drug Testing and Analysis 6 (7–8): 633–50. 2014. doi:10.1002/dta.1468. PMID 23554350. 
  2. "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis 6 (7–8): 614–32. 2014. doi:10.1002/dta.1620. PMID 24678061. 
  3. "Phencyclidine-Based New Psychoactive Substances". New Psychoactive Substances. Handbook of Experimental Pharmacology. 252. 2018. pp. 261–303. doi:10.1007/164_2018_124. ISBN 978-3-030-10560-0.