Chemistry:AT-121
From HandWiki
Short description: Chemical compound
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| Formula | C24H38N4O3S |
| Molar mass | 462.65 g·mol−1 |
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AT-121 is an experimental analgesic. It was designed to be bifunctional, acting as an agonist at both the μ-opioid receptor and the nociceptin receptor.[1] The interaction with the nociceptin receptor is expected to block the abuse and dependence-related side effects that are typical of opioids.[2] A study in nonhuman primates found that AT-121 has morphine-like analgesic effects, but suppressed the addictive effects.[1][3]
See also
References
- ↑ 1.0 1.1 "A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates". Science Translational Medicine 10 (456): eaar3483. August 2018. doi:10.1126/scitranslmed.aar3483. PMID 30158150.
- ↑ "Scientists take big step toward finding non-addictive painkiller". Science Daily. August 29, 2018. https://www.sciencedaily.com/releases/2018/08/180829143821.htm.
- ↑ "Study: Non-addictive painkiller is safe, effective in animals". UPI. August 30, 2018. https://www.upi.com/Health_News/2018/08/30/Study-Non-addictive-painkiller-is-safe-effective-in-animals/4621535636997/.
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