Chemistry:Atiprimod
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| Formula | C22H44N2 |
| Molar mass | 336.608 g·mol−1 |
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Atiprimod (INN, codenamed SK&F106615) is a substance being studied in the treatment of certain multiple myelomas and other advanced cancers. It may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. This drug is also being researched as a potential treatment for various autoimmune diseases. It was first developed by GlaxoSmithKline as a potential treatment for rheumatoid arthritis.[1] The substance is also known as azaspirane, although this more properly refers to the class of chemicals to which atiprimod belongs.
This compound has also been shown to kill mantle cell lymphoma cells in vitro.[2]
Mechanism of action
Atiprimod has been shown to inhibit angiogenesis (growth of blood vessels) in a blood vessel model using chicken eggs. It is thought to inhibit the secretion of vascular endothelial growth factor (VEGF), a growth factor that promotes angiogenesis.[citation needed]
Chemistry
Atiprimod is an amphiphilic compound and a cation at neutral pH.
Synthesis
References
- ↑ Jacobs GS (Spring 2004). "Atiprimod: A New Drug Candidate in Early-Stage Development for Myeloma". Myeloma Today (International Myeloma Foundation) 5 (10). http://myeloma.org/ArticlePage.action?tabId=0&menuId=0&articleId=1379&aTab=0. Retrieved 2010-09-30.
- ↑ "Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways". Blood 109 (12): 5455–5462. June 2007. doi:10.1182/blood-2006-12-063958. PMID 17317853.
- ↑ Dagger RE, Grady CW, "2-[2-(dimethylaminoehtyl]-8,8-diproply-2-azaspiro[4.5]decane dimaleate", US patent 5952365, issued 4 September 1999, assigned to Anormed Inc.
Further reading
External links
- Atiprimod entry in the public domain NCI Dictionary of Cancer Terms
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
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