Biology:Lipegfilgrastim
| Clinical data | |
|---|---|
| Trade names | Lonquex |
| Other names | XM-22 |
| AHFS/Drugs.com | UK Drug Information |
| License data | |
| Routes of administration | Subcutaneous injection |
| Drug class | Immunostimulants, colony-stimulating factors[1] |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Metabolism | Saturable proteolytic enzymes (not cytochrome P450 system mediated)[4] |
| Elimination half-life | 32–62 hours[4] |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| UNII | |
| KEGG | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C866H1372N226O258S9 + PEG |
| Molar mass | 39000 g·mol−1 |
Lipegfilgrastim, sold under the brand name Lonquex, is a medication used to reduce the duration of neutropenia and the incidence of febrile neutropenia in adults.[1] It is given by injection under the skin in the abdomen, upper arm or thigh.[1]
The most common side effects include nausea as well as bone and muscle pain.[1]
Lipegfilgrastim is similar to granulocyte colony stimulating factor (G‑CSF), a naturally occurring protein in the body that stimulates the production of white blood cells including neutrophils in the bone marrow.[1] Lipegfilgrastim acts in the same way as G‑CSF, increasing the production of neutrophils and thereby helping to reduce the duration of neutropenia and the occurrence of febrile neutropenia (a sign of infection) in people receiving chemotherapy.[1]
Lipegfilgrastim is a filgrastim biosimilar.[1] In lipegfilgrastim, the filgrastim has been 'pegylated' (attached to polyethylene glycol).[1] This slows down the medicine's removal from the body and allows the medicine to be given less often.[1]
Lipegfilgrastim was authorized for medical use in the European Union in July 2013.[1]
Medical uses
Lipegfilgrastim is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in adults treated with cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes).[1]
See also
- Pegfilgrastim – another pegylated filgrastim biosimilar
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 "Lonquex EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/lonquex. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ↑ "Prescription medicines: registration of new chemical entities in Australia, 2015". 21 June 2022. https://www.tga.gov.au/prescription-medicines-registration-new-chemical-entities-australia-2015.
- ↑ "Lonquex - Summary of Product Characteristics (SmPC)". 3 September 2019. https://www.medicines.org.uk/emc/medicine/28948/SPC/Lonquex/.
- ↑ 4.0 4.1 Hoggatt, J; Tate, TA; Pelus, LM (2015). "Role of lipegfilgrastim in the management of chemotherapy-induced neutropenia.". International Journal of Nanomedicine 10: 2647–52. doi:10.2147/IJN.S55796. PMID 25878498.
Further reading
- "Meta-analysis and indirect treatment comparison of lipegfilgrastim with pegfilgrastim and filgrastim for the reduction of chemotherapy-induced neutropenia-related events". J Oncol Pharm Pract 24 (6): 412–423. September 2018. doi:10.1177/1078155217714859. PMID 28614980.
- "Lipegfilgrastim in the management of chemotherapy-induced neutropenia of cancer patients". Biologics: Targets and Therapy 10: 1–8. 2016. doi:10.2147/BTT.S58597. PMID 26858523.
- "Immunogenicity Assessment of Lipegfilgrastim in Patients with Breast Cancer Receiving Chemotherapy". J Immunol Res 2016: 9248061. 2016. doi:10.1155/2016/9248061. PMID 27419145.
External links
- "Lipegfilgrastim". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/lipegfilgrastim.
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