Chemistry:BU08028
From HandWiki
Short description: Chemical compound
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| Formula | C30H43NO4 |
| Molar mass | 481.677 g·mol−1 |
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BU08028 is a drug which acts as a potent partial agonist at both the μ-opioid receptor and nociceptin receptor. It is a homologue of buprenorphine extended by just one carbon on the side chain, but has relatively greater activity at the nociceptin receptor, which is thought to reduce the abuse potential without compromising analgesia.[1][2][3][4]
See also
References
- ↑ "Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine". Journal of Medicinal Chemistry 54 (19): 6531–7. October 2011. doi:10.1021/jm2003238. PMID 21866885.
- ↑ "The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward"]. The Journal of Pharmacology and Experimental Therapeutics 336 (3): 952–61. March 2011. doi:10.1124/jpet.110.175620. PMID 21177476.
- ↑ "A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates". Proceedings of the National Academy of Sciences of the United States of America 113 (37): E5511-8. September 2016. doi:10.1073/pnas.1605295113. PMID 27573832. Bibcode: 2016PNAS..113E5511D.
- ↑ "Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse". Journal of Neuroscience Research 100 (1): 191–202. April 2020. doi:10.1002/jnr.24624. PMID 32255240.
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